The two teams previously met during the European Rugby Challenge Cup Semi-Finals in 2016, when the Region travelled to Montpellier and lost out to the star-studded side.
Following a week long training camp in France, Jackman has picked a mixture of youth and experience in his squad, which will feature Welsh International Gavin Henson as he makes his first run out in Dragons colours.
"It's going to be hard to manage, but pre-season is just about getting minutes and making sure everyone gets a fair crack to show they should be in for the first game," said Bernard Jackman.
"Montpellier have a star-studded side and our game against them will be their final prep for their Top '14 opener the next weekend. That will be a challenge - and Northampton
"The team for Montpellier will be based on what we have seen in pre-season. We'll then send 14 players back from Montpellier on Friday to meet up with a group that has stayed behind.
"The coaches will then fly to Northampton on Saturday. That means those playing against Northampton can still be judged, although we will also take into account that it's not an ideal situation because they will have very little time to train together."
Dragons squad to take on Montpellier
15 Carl Meyer
14 Adam Hughes
13 Sam Beard
12 Jack Dixon
11 Hallam Amos
10 Gavin Henson
9 Sarel Pretorius
8 Harrison Keddie
7 James Benjamin
6 James Thomas
5 Ashley Sweet
4 Matthew Screech
3 Lloyd Fairbrother
2 Elliot Dee
1 Thomas Davies
Replacements
16 Rhys Buckley
17 Phillip Price
18 Leon Brown
19 Max Williams
20 Nic Cudd
21 Charlie Davies
22 Angus O Brien
23 Pat Howard
24 Ashton Hewitt
25 Will Talbot Davies
