Fullback Joe Goodchild, who scored a crucial try in Wales' opening victory against Australia, will feature for the first time since an injury against New Zealand in round two, as one of five Dragons in the starting fifteen.
Scarlets centre Ioan Nicholas will captain Wales, having been a regular in the Guinness Pro14 last season after competing in the 2017 World Rugby U20 Championship in Georgia. Regular captain Tommy Reffell has played every minute of the tournament so far, and is this weekend named on the bench.
Changes to the pack come in the form of hooker Dewi Lake, blindside Lennon Greggains and openside Taine Basham in the back row.
In the backs Max Llewellyn will make his first start of the tournament after being called up as a replacement for the injured Rio Dyer after round one. Harri Morgan at scrum-half is the only other change.
"The players are aware of the Italians' strengths, having lost against them in Colwyn Bay a few months ago, so it's up to them to put it right tomorrow," says Lewis, who remarked that this tournament would be the making of several players.
"It was great to start our time in France with a good win, but now we'd like a positive performance and result to finish it as well."
Wales U20 v Italy U20 will be shown live across S4C's terrestrial and digital channels from 14:45.
Wales U20 team to face Italy:
15 Joe Goodchild (Dragons)
14 Corey Baldwin (Scarlets)
13 Ioan Nicholas (c) (Scarlets)
12 Max Llewellyn (Cardiff Blues)
11 Ryan Conbeer (Scarlets)
10 Cai Evans (Ospreys)
9 Harri Morgan (Ospreys)
1 Rhys Carre (Cardiff Blues)
2 Dewi Lake (Ospreys)
3 Chris Coleman (Dragons)
4 Rhys Davies (Bath Rugby)
5 Max Williams (Dragons)
6 Lennon Greggains (Dragons)
7 Dan Davis (Scarlets)
8 Taine Basham (Dragons)
Replacements:
16 Iestyn Harris (Cardiff Blues)
17 Rhys Davies (Scarlets)
18 Rhys Henry (Ospreys)
19 Jack Pope (Bridgend)
20 Tommy Reffell (Leicester Tigers)
21 Dane Blacker (Cardiff Blues)
22 Ben Thomas (Cardiff Blues)
23 Dewi Cross (Ospreys)
