The coaching team at Dragons have make six changes to the side that lost the opening game of the competition to Cardiff Blues A last week.
Loots comes in at centre, to partner captain Connor Edwards, while full back Carwyn Penny is also handed a start in the 15 jersey, with Will Talbot-Davies moving to the wing.
Scrum half Dafydd Buckland will now partner Jacob Botica at half back.
Second row Taylor is among three changes in the pack with prop Gerard Ellis and Number Eight Taine Basham, who scored against Cardiff Blues, also selected.
Calvin Wellington could get his first taste of Celtic Cup action this season after being named among the replacements.
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Dragons A (v Connacht Eagles):Carwyn Penny, Will Talbot-Davies, Connor Edwards (c), Tiaan Loots, Jared Rosser, Jacob Botica, Dafydd Buckland; Gerard Ellis, Rhys Lawrence, Chris Coleman, Joe Davies, Huw Taylor, Lennon Greggains, James Benjamin, Taine Basham
Replacements: Zac Hewlett, Scott Evans, Luke Yendle, Max Williams, Ben Fry, Dan Babos, Joe Goodchild, Calvin Wellington
Connacht: 15 Darragh Leader, 14 Rory Scholes, 13 Sean O'Brien 12 Kieran Joyce 11 Colm de Buutlear 10 Conor Fitzgerald 9 Conor McKeon, 1 Matthew Burke 2 Tom McCartney (c) 3 Conor Carey 4 Peter Claffey 5 Joe Maksymiw 6 Cillian Gallagher 7 Cian Huxford 8 RobinCopeland
Replacements: 16 Jonny Murphy 17 Jordan Duggan 18 Conor Kenny 19 Cormac Daly 20 Neal Moylett 21 James Mitchell 22 Conor Dean 23 Conor Hayes