Jamie Roberts and Jonah Holmes will make their debuts as Dragons face Bristol Bears in the quarter-finals of the European Challenge Cup at Ashton Gate on Friday (kick-off 7.45pm).
Vastly experienced centre Roberts will link-up with Nick Tompkins in midfield while Wales international Holmes adds his firepower out wide.
Dean Ryan, Director of Dragons Rugby, also hands a sensational return to action to full back Jordan Williams, one of a total of seven changes from the side that last featured in the Guinness PRO14.
The eye-catching No.15 will return to his former club for the European showdown as he makes his first appearance since November last year.
Wales international Leon Brown and Brok Harris are named up front to scrum down alongside hooker Elliot Dee.
Destructive Number Eight Ross Moriarty is back in the pack while a back row reshuffle will see Aaron Wainwright operate at blindside flanker and Harrison Keddie move to openside.
The final change to the starting line-up is a recall for lock Joe Davies who will partner Matthew Screech in the second row.
There is also a welcome return for fly half Josh Lewis who could make his first appearance for Dragons since April 2019 after being named among the replacements.
“We’re all really looking forward to the quarter-final and we’re going to give it everything we’ve got,” said Ryan.
“We’ve worked hard over the last few weeks, and across our final two league games, to ensure we got the right 15 out on the field.
“We’ve had to make some calls on selection and the players we feel can make an impact.
“There is real excitement in the squad and we have some big games players who are determined to make an impression in this game.”
Dragons (v Bristol Bears): Jordan Williams, Jonah Holmes, Nick Tompkins, Jamie Roberts, Ashton Hewitt, Sam Davies, Rhodri Williams (c); Brok Harris, Elliot Dee, Leon Brown, Joe Davies, Matthew Screech, Aaron Wainwright, Harrison Keddie, Ross Moriarty
Replacements: Richard Hibbard, Josh Reynolds, Lloyd Fairbrother, Joe Maksymiw, Taine Basham, Luke Baldwin, Josh Lewis, Adam Warren
There is real excitement in the squad and we have some big games players who are determined to make an impression in this game...
