Wing Ashton Hewitt will make his 100th appearance for Dragons when he lines up in the Guinness PRO14 clash with Ospreys at the Brewery Field on Saturday evening (kick-off 7.35pm).
Hewitt, who made his regional debut back in 2013, hits the memorable milestone as Dragons aim to return to winning ways in the Round 14 fixture in Bridgend.
Director of Dragons Rugby, Dean Ryan, makes a total of five changes to the side that faced Zebre last weekend.
Wales international Aaron Wainwright returns in the back row and will wear the Number Eight jersey. Ross Moriarty moves to blindside while Harrison Keddie captains from openside.
Prop Brok Harris is back up front while lock Joe Davies is recalled to partner Joe Maksymiw in the second row.
Centre Jamie Roberts is named at inside centre, alongside Aneurin Owen, while the final change is a start for Josh Lewis at full back.
Richard Hibbard, Aaron Jarvis and Dan Baker could all face their former region after being named among the replacements.
“We’re looking forward to a derby game and are eager to produce a better performance after last weekend,” said Ryan.
“Derby games always create a bit more emotion, a little more clarity and we hope that we can give a better representation of ourselves.
“It’s a new environment for us down at Bridgend and a challenge we should relish rather than have any concerns about. We’re excited about the game and what we can produce.”
Dragons (v Ospreys): Josh Lewis, Jonah Holmes, Aneurin Owen, Jamie Roberts, Ashton Hewitt, Sam Davies, Gonzalo Bertranou; Brok Harris, Ellis Shipp, Lloyd Fairbrother, Joe Davies, Joe Maksymiw, Ross Moriarty, Harrison Keddie (c), Aaron Wainwright
Replacements: Richard Hibbard, Josh Reynolds, Aaron Jarvis, Ben Carter, Dan Baker, Rhodri Williams, Jack Dixon, Jordan Williams