Wales Head Coach Wayne Pivac has announced four Dragons in the squad to take on World Champions South Africa at the Principality Stadium on Saturday.
Lock Will Rowlands comes into the side to join Taine Basham and Aaron Wainwright in the starting XV.
Fellow Dragons second row Ben Carter is also named in the squad as he takes a place amongst the replacements.
Having lost the services of captain Alun Wyn Jones and back rower Ross Moriarty to injuries, and welcoming the English-based players into camp this week, Wales head coach Wayne Pivac has made six changes to the starting XV that took to the field against New Zealand last weekend.
Loosehead prop Rhys Carré comes into the front row alongside hooker Ryan Elias and tighthead prop Tomas Francis, with Wyn Jones moving to the replacements bench.
Dragons lock Rowlands links up with Ospreys' Adam Beard in the second row to win his 12th international cap.
Cardiff Rugby’s Ellis Jenkins comes in for Moriarty in the back row, making his long-awaited return to international injury after suffering a knee injury against South Africa three years ago. Dragons pair Taine Basham and Aaron Wainwright retain their places at seven and No8 respectively.
Scrum half Tomos Williams remains at scrum half while the experienced fly half Dan Biggar, making his 93rd international appearance, returns to the starting line-up after a summer touring with the British & Irish Lions.
Saracens centre Nick Tompkins partners captain Jonathan Davies in midfield, with Louis Rees-Zammit linking up in the back three with fellow winger Josh Adams and fullback Johnny McNicholl.
The replacements include two debutants, hooker Bradley Roberts and tighthead prop WillGriff John, who will be looking to win their first international caps.
Fullback Liam Williams has made a return to fitness, after undergoing an appendectomy, and will take part in his first game of rugby since the last British & Irish Test, against South Africa, back in August.
“South Africa coming to town, as world champions, offers a different challenge to New Zealand. They’ve got a massive forward pack, they’re big across the park really, and they bring a huge aerial threat so it’s going to be a different challenge,” said Pivac.
“It’s a big Test match and we need to get what we think is the best side out there. We’re looking forward to having this side out there on the weekend and it’ll be really interesting to see how we go.
“There’s a lot of experience gone from the pack now and with what’s coming in terms of the South African pack, with their experience, it’s going to be a massive challenge for our boys and it’ll be interesting to see who steps up.
“Field position in this game is going to be massive, with the scrum that’s coming and line out drive, so we have to make sure we’re smart in how we play the game.
Wales team to face South Africa, at Principality Stadium, on Sat 6th November 2021
15 Johnny McNicholl (Scarlets)
14 Louis Rees-Zammit (Gloucester Rugby)
13 Jonathan Davies (Scarlets - Capt)
12 Nick Tompkins (Saracens)
11 Josh Adams (Cardiff Rugby)
10 Dan Biggar (Northampton Saints)
9 Tomos Williams (Cardiff Rugby);
1 Rhys Carré (Cardiff Rugby)
2 Ryan Elias (Scarlets)
3 Tomas Francis (Ospreys)
4 Will Rowlands (Dragons)
5 Adam Beard (Ospreys)
6 Ellis Jenkins (Cardiff Rugby)
7 Taine Basham (Dragons)
8 Aaron Wainwright (Dragons)
Replacements;
16 Bradley Roberts (Ulster - uncapped)
17 Wyn Jones (Scarlets)
18 WillGriff John (Scarlets - uncapped)
19 Ben Carter (Dragons)
20 Seb Davies (Cardiff Rugby)
21 Gareth Davies (Scarlets)
22 Gareth Anscombe (Ospreys)
23 Liam Williams (Scarlets)