Full back Jordan Williams and centre Jack Dixon return to the side as Dragons face Munster Rugby in the United Rugby Championship at Thomond Park on Saturday afternoon (kick-off 5.15pm).
The back duo are recalled as boss Dean Ryan makes five changes to his starting line-up for the Limerick fixture.
Wales international Aaron Wainwright is back at Number Eight after being released back to the region from Six Nations duty, with captain Harrison Keddie and Ollie Griffiths joining him in the back row.
Scrum half Rhodri Williams returns to partner Sam Davis at half back while there is also a call-up for Will Talbot-Davies, who makes his first start of the season on the wing.
Fit-again scrum half Lewis Jones and back row Ben Fry are set to make comebacks from the replacements bench while hooker Ellis Shipp is also named. Elliot Dee misses the game through injury.
“Munster are direct with a clear kicking game, and they are very physical in the forwards. If they get momentum, then they are really threatening out the back too,” said Ryan.
“To go Ulster and then into Munster is huge challenge, but I thought there was significant improvement in terms of our physicality last time out. I want to see that continue this week.
“It’s a welcome return for Jack Dixon and Jordan Williams and we look forward to seeing how they can contribute something different.”
Ross Moriarty, Will Rowlands, Leon Brown, Ben Carter and Taine Basham remain away with Wales while Cory Allen, Lloyd Fairbrother, Ashton Hewitt are among those ruled out through injury.
Dragons: Jordan Williams, Will Talbot-Davies, Jack Dixon, Aneurin Owen, Rio Dyer, Sam Davies, Rhodri Williams; Greg Bateman, Taylor Davies, Chris Coleman, Joe Davies, Joe Maksymiw, Harri Keddie (c), Ollie Griffiths, Aaron Wainwright
Replacements: Ellis Shipp, Aki Seiuli, Mesake Doge, Huw Taylor, Ben Fry, Dan Baker, Lewis Jones, Josh Lewis