Dragons RFC quartet Aaron Wainwright, Elliot Dee, Rio Dyer and Cai Evans all featured as Wales led for 54 minutes at Twickenham and made England dig deep to come from behind to eventually win 16-14.
A youthful and spirited Wales side led at the break as they claimed a penalty try before an Alex Mann score threatened a first win in London since 2015.
Fraser Dingwall scored in the corner to drag England to within a point before George Ford's penalty sealed victory.
Victory moved England to the top of the Six Nations table - after they maintained their winning start to the tournament - while Wales claimed a losing bonus point and remain fifth despite two opening defeats.
Congratulations to all four Dragons for impressing in a breathless Six Nations encounter.
