New Wales head coach Steve Tandy's reign began with a heavy 52-28 defeat as Argentina powered to a record win in a match of 11 tries at Principality Stadium.
It was a 10th successive home defeat for Wales, who also lost inspirational captain Jac Morgan to what Tandy later revealed was a suspected dislocated shoulder.
Flanker Morgan suffered the problem in the act of scoring one of Wales' four tries, while Dragons RFC Number Eight Aaron Wainwright was also forced off.
Argentina crossed for seven tries, with fly-half Geronimo Prisciantelli's double supplemented by scores from prop Pedro Delgado, scrum-half Simon Benitez Cruz, wings Mateo Carreras and Bautista Delguy and replacement Santiago Grondona, while full-back Santiago Carreras kicked 17 points.
Wales responded with tries from scrum-half Tomos Williams, hooker Dewi Lake, Morgan and full-back Blair Murray.
Wales next face Japan at Principality Stadium next Saturday (November 15).
