Dragons duo Ben Carter and Aaron Wainwright start again for Wales as they take on Ireland on Friday night (kick-off 8.10pm).
Both Carter and Wainwright started the narrow defeat to Scotland last time out and now travel to Dublin to face an Irish side who have won their last two in the Championship.
Elsewhere, there are three changes to the starting XV. James Botham is named at openside flanker, Edwards is back at fly-half, while Ellis Mee starts on the wing.
Among the replacements, Louie Hennessey is in line to make his senior international debut while Adam Beard and Olly Cracknell join the forward cover for this match.
Tandy said: “There are a couple of enforced changes this week due to injury and then Ellis had played well in the opening couple of rounds, so we feel he deserves the opportunity again.”
“This week it's about backing up the performance against Scotland. Going away from home is a different type of environment for our group, but the focus for us is really improving on what we did last game.
“I thought the defence against Scotland was much improved so we definitely want to double down on that going to Ireland.
“You see how they keep the ball in possession, they play lots of passes so we know we're going to have to build and improve from the other week.”
Wales team v Ireland – Guinness Six Nations
15. Louis Rees-Zammit (Bristol Bears | Bryste – 38 caps); 14. Ellis Mee (Scarlets – 6 caps), 13. Eddie James (Scarlets – 7 caps), 12. Joe Hawkins (Scarlets – 9 caps), 11. Josh Adams (Cardiff Rugby | Caerdydd – 68 caps); 10. Dan Edwards (Ospreys | Gweilch – 9 caps), 9. Tomos Williams (Gloucester Rugby | Caerloyw – 70 caps); 1. Rhys Carre (Saracens | Saraseniaid – 26 caps), 2. Dewi Lake (Ospreys | Gweilch – 29 caps) captain | capten, 3. Tomas Francis (Provence Rugby – 80 caps), 4. Dafydd Jenkins (Exeter Chiefs | Caerwysg – 29 caps), 5. Ben Carter (Dragons / Dreigiau – 17 caps), 6. Alex Mann (Cardiff Rugby | Caerdydd – 14 caps), 7. James Botham (Cardiff Rugby | Caerdydd – 19 caps), 8. Aaron Wainwright (Dragons | Dreigiau – 65 caps).
Replacements | Eilyddion
16. Ryan Elias (Scarlets – 46 caps), 17. Nicky Smith (Leicester Tigers | Caerlŷr – 61 caps), 18. Archie Griffin (Bath Rugby | Caerfaddon – 14 caps), 19. Adam Beard (Montpellier – 63 caps), 20. Olly Cracknell (Leicester Tigers | Caerlŷr – 3 caps), 21. Kieran Hardy (Ospreys | Gweilch – 30 caps), 22. Jarrod Evans (Harlequins – 16 caps), 23. Louie Hennessey (Bath Rugby | Caerfaddon – uncapped / heb gap).
