The Dragons travel with three wins under their belt, the latest in North Wales, while the Blues are two from two in the new Under 25 tournament.
As well as the title, the players from all the regions have got one eye firmly fixed on winning a Welsh cap in the new Amateur XV that the Welsh Rugby Union will be launching later in the year.
Blues (from): Gwyn Pengelly (Brecon), Gavin Close (Rhydyfelin), Daniel Palk (Beddau), Dano Roberts (Ystrad Rhondda), Ian Blackburn (Rumney), Vivian Rees (Fairwater), Nathan Walters (Beddau), Rhys McCarthy (Fairwater), Rob Saunders (Cowbridge), Rhys Jenkins (Beddau), Matthew Turner (Abercynon); Owen Cotton (Ynysbwl), Dean Lloyd (Tylorstown), Chris Lloyd (Tylorstown), Jon Watkins (UWIC), Matthew Hunt (Beddau), Steven Bullock (Llantwit Major), Leigh Davies (Llanharan), Jeff Steele (Pentyrch), Gareth Keetch (Cilfynydd), Andy McKeown (Old Illtydians), Dave Hefford (Abercynon), David Ince (Pentyrch), Rob Downes (Beddau), Rhys Watkins (Taffs Well), Geraint Turner (Abercynon).
Dragons (from): Shaun Thomas (Blaina), Nathan Gittins (Fleur De Lys), Rob Smith (Blackwood), Karl Rees (Penallta), Lee Pearson (Bargoed), David James ( Blackwood), Shaun Powell (Penallta), Darren Humphries (Bargoed), Phil Price (Caerphilly), Jamie Howells (Bargoed), Rhodri Jones (Talywain), Leighton Burrows (Pill Harriers), Mark Throrogood (Pill Harriers); Anthony Lott (Bargoed, Captain), Daniel Preece (Brynmawr), Kristian Gay (Tredegar), Ross Jones (Bargoed), Peter Harrison (Caerphilly), Mark Davies (Fleur De Lys), Jamie Noble (Blaina), Lee Williams (Croesyceiliog), Simon Jones (Blackwood), Andrew Packer (Caerphilly), Richard Walker (Newport Saracens), Ross Palmer (Pill Harriers), Lee Edwards (Tredegar), David Brake (Caerphilly).